Interactions of some alpha-amino acids with antibacterial drug gentamicin sulphate in aqueous medium probed by using physicochemical approaches

摘要

The amino acid-drug interactions have been examined by using measurements of physical properties, such as densities, rho, ultrasonic speeds, u and viscosities, eta of glycine, l-alanine, l-valine and l-isoleucine in aqueous-gentamicin sulphate solvents at the temperatures from 293.15 to 318.15 K with intervals of 5 . K. The rho data are used to calculate the apparent molar properties, V-phi, V-phi degrees, and the transfer volumes, V-phi,V-tr degrees. From the u data, the apparent molar isentropic compressibilities, K-s,K-phi, K-s,K-phi degrees and the transfer cornpressibilities, K-s,K-phi,K-tr degrees have been evaluated. The eta data were used to evaluate Falkenhagen coefficient, A, Jones-Dole coefficient, B. The enthalpies, Delta H degrees(#) and entropies, Delta S degrees(#) and activation parameters, Delta mu(1)degrees(#) and Delta mu(2)degrees(#) of viscous flow were also calculated. The effect of concentration, temperature and solute structure were discussed in terms of solute-solvent and solute-solute interactions prevailing in these systems. The structure making/breaking ability of amino acids has also been examined using temperature derivative of B-coefficient, dB/dT. In addition, the values of V-phi degrees, K-s,K-phi degrees, B and Delta mu(2)degrees(#) have also been split into groups' contributions of the amino acids. (C) 2020 Elsevier B.V. All rights reserved.