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机译:通过Irak4激酶抑制和蛋白质降解评估ABC DLBCL中的Irak4功能
Oncology Biology Janssen (China) Research &
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Medicinal Chemistry Janssen (China) Research &
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Oncology Biology Janssen (China) Research &
Development Center;
Medicinal Chemistry Janssen (China) Research &
Development Center;
Oncology Biology Janssen (China) Research &
Development Center;
Biomarker Janssen (China) Research &
Development Center;
Medicinal Chemistry Janssen (China) Research &
Development Center;
Biomarker Janssen (China) Research &
Development Center;
Nonclinical Safety Janssen (China) Research &
Development Center;
Janssen Research &
Development LLC;
Oncology Biology Janssen (China) Research &
Development Center;
Medicinal Chemistry Janssen (China) Research &
Development Center;
Medicinal Chemistry Janssen (China) Research &
Development Center;
Oncology Biology Janssen (China) Research &
Development Center;
Biomarker Janssen (China) Research &
Development Center;
Oncology Biology Janssen (China) Research &
Development Center;
Janssen Research &
Development LLC;
Janssen Research &
Development LLC;
Janssen Research &
Development;
Janssen Research &
Development LLC;
Oncology Biology Janssen (China) Research &
Development Center;
Medicinal Chemistry Janssen (China) Research &
Development Center;
Janssen Research &
Development LLC;
Medicinal Chemistry Janssen (China) Research &
Development Center;
interleukin-1 receptor activated kinase 4 (IRAK4); proteolysis-targeting chimera; PROTAC; selective IRAK4 degrader; activated B-cell-like diffuse large B cell lymphoma; ABC DLBCL; myeloid differentiation primary response 88 signaling; MyD88; scaffolding activity of IRAK4; IRAK4 PROTAC;
机译:完全依赖于TLR2中IRAK4激酶活性,但不完全依赖TLR4,这表明IRAK4激酶失活的小鼠体内细胞因子的产生和肺炎链球菌感染的易感性是信号通路的基础
机译:完全依赖TLR2中IRAK4激酶活性的依赖性,但不完全依赖TLR4信号通路,这是导致IRAK4激酶失活的小鼠中细胞因子产生减少和对肺炎链球菌感染的敏感性增加的基础
机译:Irak4激酶活性的抑制改善了小鼠乙醇诱导的肝损伤
机译:AMP活化蛋白激酶对氧化细胞中的缺氧对细胞特异性Ca〜(2+)信号传导机制进行线粒体抑制
机译:IRAK4激酶活性在TLR / IL-1R介导的信号传导中的作用
机译:在IRaK4激酶活性TLR2但不是TLR4信号转导途径Underlies完全依赖减少细胞因子的产生和易感性增加肺炎链球菌感染IRaK4激酶失活小鼠
机译:IRAK4通过抑制蛋白激酶B将IL-10(+)磷酸-FOXO +单核细胞转变为促炎细胞
机译:pI3-激酶/ akt / eNOs信号通过抑制小鼠肺中p38丝裂素活化蛋白激酶对机械应激的保护作用