首页> 外文期刊>Cancer letters >Hypoxia-induced miR-214 expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells
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Hypoxia-induced miR-214 expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells

机译:缺氧诱导的miR-214表达通过提高胃癌细胞中的Warburg效应来促进肿瘤细胞增殖和迁移

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摘要

Abstract miR-214 is an important oncomiRNA and is upregulated in various types of cancer, including gastric cancer. However, the molecular mechanism underlying the ectopic expression and function of miR-214 in gastric cancer is largely undefined. In this study, we found that miR-214 induces the Warburg effect and promotes the migration and proliferation of human gastric cancer cells. According to the mechanistic analysis, miR-214 expression is induced by environmental hypoxia, and miR-214 mediates hypoxia-induced functions. We then explored the molecular mechanism by which miR-214 enhances the Warburg effect in gastric cancer cells and identified the adenosine A2A receptor (A2AR) and PR/SET domain 16 (PRDM16) genes as the direct targets of miR-214. In conclusion, miR-214 inhibits A2AR and PRDM16 expression and enhances the Warburg effect in gastric cancer cells, thus promoting the proliferation and migration of gastric cancer cells. This study highlights an important role for the hypoxia-miR-214-PRDM16/A2AR pathway in the tumourigenesis of gastric cancer and may facilitate the development of new therapeutics against hypoxic tumours.
机译:摘要miR-214是一种重要的癌基因miRNA,在包括胃癌在内的多种癌症中表达上调。然而,miR-214在胃癌中异位表达和功能的分子机制在很大程度上尚不明确。在这项研究中,我们发现miR-214诱导Warburg效应,并促进人类胃癌细胞的迁移和增殖。根据机理分析,miR-214的表达是由环境缺氧诱导的,miR-214介导缺氧诱导的功能。然后,我们探索了miR-214增强胃癌细胞Warburg效应的分子机制,并确定腺苷A2A受体(A2AR)和PR/SET结构域16(PRDM16)基因是miR-214的直接靶点。总之,miR-214抑制胃癌细胞中A2AR和PRDM16的表达,并增强Warburg效应,从而促进胃癌细胞的增殖和迁移。这项研究强调了低氧-miR-214-PRDM16/A2AR通路在胃癌发生中的重要作用,并可能促进针对低氧肿瘤的新疗法的开发。

著录项

  • 来源
    《Cancer letters》 |2018年第2018期|共13页
  • 作者单位

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

    Department of General Surgery Drum Tower Hospital Medical School of Nanjing University;

    State Key Laboratory of Pharmaceutical Biotechnology Collaborative Innovation Center of Chemistry;

    Division of Gastroenterology and Hepatology Shanghai Renji Hospital School of Medicine Shanghai;

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

    Department of General Surgery Taixing Hospital Medical School of Yangzhou University;

    State Key Laboratory of Pharmaceutical Biotechnology Collaborative Innovation Center of Chemistry;

    State Key Laboratory of Pharmaceutical Biotechnology Collaborative Innovation Center of Chemistry;

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

    Department of Gastroenterology Drum Tower Hospital Medical School of Nanjing University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    miR-214; PRDM16; A2AR; Hypoxia; Warburg effect; Gastric carcinoma;

    机译:mir-214;prdm16;a2ar;缺氧;沃斯堡效应;胃癌;

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