Downregulation of lncRNA ZEB1-AS1 Represses Cell Proliferation, Migration, and Invasion Through Mediating PI3K/AKT/mTOR Signaling by miR-342-3p/CUL4B Axis in Prostate Cancer

Ma Teng; Chen Hua; Wang Peilong; Yang Ningqiang; Bao Junsheng

首页> 外文期刊>Cancer biotherapy and radiopharmaceuticals >Downregulation of lncRNA ZEB1-AS1 Represses Cell Proliferation, Migration, and Invasion Through Mediating PI3K/AKT/mTOR Signaling by miR-342-3p/CUL4B Axis in Prostate Cancer

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Downregulation of lncRNA ZEB1-AS1 Represses Cell Proliferation, Migration, and Invasion Through Mediating PI3K/AKT/mTOR Signaling by miR-342-3p/CUL4B Axis in Prostate Cancer

机译：LNCRNA Zeb1-AS1的下调通过MiR-342-3P / Cul4B轴在前列腺癌中介导PI3K / AKT / MTOR信号传导来压制细胞增殖，迁移和侵袭

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Background: Prostate cancer (PCa) is the second most common cancer among men, threatening men's health and life. Long noncoding RNA Zinc-finger E-box binding homeobox 1 antisense gene 1 (ZEB1-AS1) and Cullin 4B (CUL4B) were reported to be connected with the tumorigenesis of PCa. However, it is unclear whether ZEB1-AS1 regulates the expression of CUL4B in PCa.

机译：背景：前列腺癌（PCa）是男性第二常见的癌症，威胁着男性的健康和生命。据报道，长非编码RNA锌指E盒结合同源框1反义基因1（ZEB1-AS1）和Cullin 4B（CUL4B）与PCa的肿瘤发生有关。然而，尚不清楚ZEB1-AS1是否调节PCa中CUL4B的表达。

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来源
《Cancer biotherapy and radiopharmaceuticals 》 |2020年第9期| 共12页
作者
Ma Teng; Chen Hua; Wang Peilong; Yang Ningqiang; Bao Junsheng;
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作者单位

Lanzhou Univ Urol Inst Dept Urol Gansu Key Lab Urinary Syst Hosp 2 82 Cuiyingmen Lanzhou;

Lanzhou Univ Urol Inst Dept Urol Gansu Key Lab Urinary Syst Hosp 2 82 Cuiyingmen Lanzhou;

Lanzhou Univ Urol Inst Dept Urol Gansu Key Lab Urinary Syst Hosp 2 82 Cuiyingmen Lanzhou;

Lanzhou Univ Urol Inst Dept Urol Gansu Key Lab Urinary Syst Hosp 2 82 Cuiyingmen Lanzhou;

Lanzhou Univ Urol Inst Dept Urol Gansu Key Lab Urinary Syst Hosp 2 82 Cuiyingmen Lanzhou;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学 ;
关键词
CUL4B; miR-342-3p; PCa; PI3K; AKT; mTOR; ZEB1-AS1;

机译：CUL4B;MIR-342-3P;PCA;PI3K;AKT;MTOR;Zeb1-AS1;

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1. hsa_circ_0062019 promotes the proliferation,migration,and invasion of prostate cancer cells via the miR-195-5p/HMGA2 axis [J] . Peiyu Wang, Ligang Zhang, Shuiping Yin, 生物化学与生物物理学报：英文版 . 2021 ,第007期
2. FAM83D inhibits autophagy and promotes proliferation and invasion of ovarian cancer cells via PI3K/AKT/mTOR pathway [J] . Hongtao Zhu, Shuai Diao, Vincent Lim, 生物化学与生物物理学报：英文版 . 2019 ,第005期
3. Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation,invasion,and 5-fluorouracil resistance [J] . Guangxian Mao, Zhimin Mu, Da Wu 生物化学与生物物理学报：英文版 . 2021 ,第011期
4. Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling [J] . Qing-Qing Yin, Lin-Hui Xu, Mi Zhang, 亚洲男性学杂志（英文版） . 2018 ,第006期
5. Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-KB signaling pathways [J] . Lei L(U), Dong TANG, Liang WANG, 中国药理学报：英文版 . 2012 ,第004期
6. Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway [J] . Hong Xin, Hong Xingyu, Zhao Haomin, Journal of biochemical and molecular toxicology . 2019 ,第1期

机译：SRPX2的敲低通过PI3K / AKT / MTOR信号通路抑制前列腺癌细胞的增殖，迁移和侵袭
7. Proliferation, migration and invasion of triple negative breast cancer cells are suppressed by berbamine via the PI3K/Akt/MDM2/p53 and PI3K/Akt/mTOR signaling pathways [J] . Liu Lili, Yan Jiadong, Cao Ying, Oncology letters . 2021 ,第1期

机译：通过PI3K / AKT / MDM2 / P53和PI3K / AKT / MT信号传导途径通过Berbamine抑制三阴性乳腺癌细胞的增殖，迁移和侵袭
8. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells [J] . Hong-Wei Zhang, Jin-Jiao Hu, Ruo-Qiu Fu, Scientific reports. . 2018 ,第1期

机译：类黄酮通过下调PI3Kγ介导的PI3K / AKT / mTOR / p70S6K / ULK信号通路抑制人乳腺癌细胞的增殖并诱导细胞凋亡和自噬
9. Ang-2 promoting proliferation of SW1116 colon cancer cells through PI3K/Akt pathways [C] . Hong Zhang Ji, Yang Wen Chun, Ping Wang Ai, 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：Ang-2通过PI3K / Akt途径促进SW1116结肠癌细胞的增殖
10. SIRT1 represses estrogen-signaling, ligand-independent estrogen receptor alpha-mediated transcription, and cell proliferation in breast cancer cells via inhibition of the phosphoinositide 3-kinases pathway [D] . Moore, Robert L. 2011

机译：SIRT1通过抑制磷酸肌醇3激酶途径抑制雌激素信号传导，配体独立的雌激素受体α介导的转录和乳腺癌细胞的增殖
11. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells [O] . Hong-Wei Zhang, Jin-Jiao Hu, Ruo-Qiu Fu, -1

机译：类黄酮通过下调PI3Kγ介导的PI3K / AKT / mTOR / p70S6K / ULK信号通路抑制人乳腺癌细胞的增殖并诱导细胞凋亡和自噬
12. Retracted : Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway [O] . 2018

机译：缩回：SRPX2的敲低通过PI3K / AKT / MTOR信号传导途径抑制前列腺癌细胞的增殖，迁移和侵袭
13. Cotargeting the lncRNA-PIP3 Interaction and AKT/PI3K Signaling Axis: A Novel Paradigm for Treating Triple-Negative Breast Cancer. [R] . Yang, L. 2017

机译：共定位lncRNa-pIp3相互作用和aKT / pI3K信号轴：一种治疗三阴性乳腺癌的新范式。

Downregulation of lncRNA ZEB1-AS1 Represses Cell Proliferation, Migration, and Invasion Through Mediating PI3K/AKT/mTOR Signaling by miR-342-3p/CUL4B Axis in Prostate Cancer

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