Impact of renal function on hydroxyurea exposure in sickle-cell disease patients

Pressiat Claire; Rakotoson Marie-Georgine; Habibi Anoosha; Barau Caroline; Arrouasse Raphaele; Galacteros Frederic; Stehle Thomas; Audard Vincent; Hulin Anne; Bartolucci Pablo

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Impact of renal function on hydroxyurea exposure in sickle-cell disease patients

机译：肾功能对镰状细胞病患者羟基脲暴露的影响

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Aims This prospective study aimed to develop a population pharmacokinetics (PK) model of hydroxyurea (HU) in patients with sickle cell disease. This model can be used to determine the impact of glomerular filtration rate (GFR) on HU kinetics.

机译：目的本前瞻性研究旨在建立镰状细胞病患者体内羟基脲（HU）的群体药代动力学（PK）模型。该模型可用于确定肾小球滤过率（GFR）对HU动力学的影响。

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来源
《British Journal of Clinical Pharmacology》 |2021年第5期|共12页
作者
Pressiat Claire; Rakotoson Marie-Georgine; Habibi Anoosha; Barau Caroline; Arrouasse Raphaele; Galacteros Frederic; Stehle Thomas; Audard Vincent; Hulin Anne; Bartolucci Pablo;
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作者单位

Univ Paris Est Creteil Hop Univ Henri Mondor AP HP Lab Pharmacol Creteil France;

Univ Paris Est Creteil Hop Univ Henri Mondor AP HP Ctr Reference Syndromes Drepanocytaires;

Univ Paris Est Creteil Hop Univ Henri Mondor AP HP Ctr Reference Syndromes Drepanocytaires;

Univ Paris Est Creteil Hop Univ Henri Mondor AP HP Plateforme Ressources Biol Creteil France;

Univ Paris Est Creteil Hop Univ Henri Mondor AP HP INSERM Ctr Invest Clin 1430 Creteil France;

Univ Paris Est Creteil Hop Univ Henri Mondor AP HP Ctr Reference Syndromes Drepanocytaires;

Hop Univ Henri Mondor AP HP Serv Nephrol &

Transplantat Creteil France;

Hop Univ Henri Mondor AP HP Serv Nephrol &

Transplantat Creteil France;

Univ Paris Est Creteil Hop Univ Henri Mondor AP HP Lab Pharmacol Creteil France;

Univ Paris Est Creteil Hop Univ Henri Mondor AP HP Ctr Reference Syndromes Drepanocytaires;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
glomerular hyperfiltration; hydroxyurea; moderate chronic kidney disease; sickle cell disease;

机译：肾小球超滤育;羟基脲;中度慢性肾病;镰状细胞病;

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1. Evaluation of restenosis, renal function and blood pressure after the renal artery stenting in patients with atherosclerosis renovascular disease [J] . 王焱中国医学文摘：内科学分册（英文版） . 2006,第004期
2. Effects of renal artery stenting on renal function and blood pressure in patients with atherosclerotic renovascular disease [J] . 张奇, 沈卫峰, 张瑞岩, 中华医学杂志（英文版） . 2003,第010期
3. Impact of renal function of patients on the pharmacokinetics of hydroxyurea in normal-renal, hyperfiltrating and renal failure sickle cell disease patients [J] . Fundamental & clinical pharmacology. . 2019,第S1期

机译：患者肾功能对正常肾，高滤育和肾功能衰竭镰状细胞病患者的羟基脲患者肾功能的影响
4. Hydroxyurea usage awareness among patients with sickle-cell disease in Saudi Arabia [J] . Mortadah Alsalman, Hussain Alkhalifa, Ali Alkhalifa, Health Science Reports . 2021,第4期

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5. Treatment patterns and economic burden of sickle-cell disease patients prescribed hydroxyurea: a retrospective claims-based study [J] . Nirmish Shah, Menaka Bhor, Lin Xie, Health and Quality of Life Outcomes . 2019,第1期

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6. Physical and psychological functions in patients with the end-stage renal disease [C] . Mahrova A., Svagrova, K., International Congress on Nutrition and Metabolism in Renal Disease . 2012

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7. Impact of periodontal therapy on metabolic and inflammatory markers in patients with end stage renal disease [D] . Wehmeyer, Meggan M.H. 2010

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8. Treatment patterns and economic burden of sickle-cell disease patients prescribed hydroxyurea: a retrospective claims-based study [O] . Nirmish Shah, Menaka Bhor, Lin Xie, 2019

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9. Impact of cumulative intravascular contrast exposure on renal function in patients with occlusive and aneurysmal vascular disease [O] . Kougias Panos, Sharath Sherene, Barshes Neal R., 2014

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10. Guidance for Industry. Pharmacokinetics in Patients with Impaired Renal Function211 Study Design, Data Analysis, and Impact on Dosing and Labeling [R] . 1998

机译：工业指南。肾功能受损患者的药代动力学211研究设计，数据分析以及对剂量和标记的影响

Impact of renal function on hydroxyurea exposure in sickle-cell disease patients

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