Synthesis of a DNA-Encoded Library of Pyrrolo[2,3-d]pyrimidines

摘要

Developing DNA-encoded libraries of privileged scaffolds,such as pyrrolopyrimidines,is of great interest in drug discovery and chemical biology as a powerful tool to rapidly and inexpensively discover potent drug candidates.However,it is often challenging to construct such DNA-encoded libraries because many reaction conditions are not compatible with DNA.Here,we describe the development of a convenient solid-phase synthetic strategy that overcomes the current limitations and allows the efficient synthesis of a DNA-encoded combinatorial library of structurally diverse tetra-substituted pyrrolo[2,3-d]pyrimidines.