Ruthenium-Catalyzed Asymmetric Propargylic Substitution Reactions of Propargylic Alcohols with Acetone

摘要

In sharp contrast to enantioselective allylic substitution reactions of allylic alcohol derivatives with nucleophiles catalyzed by transition metal complexes,its propargylic version has not yet been developed.We recently disclosed that ruthenium-catalyzed propargylic substitution reactions of propargylic alcohols with a variety of heteroatom- and carbon-centered nucleophiles affords the corresponding functionalized propargylic compounds in high yields with complete regioselectivity.