Aspirin resistance are associated with long-term recurrent stroke events after ischaemic stroke

摘要

Highlights ? Stroke patients with aspirin resistance (AR) exhibit an increased risk of recurrent stroke. ? The risk of stroke recurrence in the AR group was significantly higher than in the AS group. ? AR was associated with a higher risk of stroke recurrence, and increased by 365%. ? Laboratory tests for AR should be considered in stroke patients who taking aspirin. Abstract Objective To investigate the prevalent of aspirin resistance (AR) in stroke and its association with recurrent stroke in 214 patients with ischemic stroke who were receiving aspirin before the stroke onset. Methods Two hundreds and fourteen acute stroke patients who previously received aspirin therapy (100mg/day for ≥7days) were enrolled. Whole blood samples were collected for platelet aggregation testing. The result is expressed in aspirin reaction units (ARU). A cutoff of 550 ARU was used to determine the presence of AR. A follow-up period of 1year was performed to record stroke recurrence events. Results In this study, the median age was 68 years (IQR, 60–77 years), and 118 (55.1%) were men. A total of 43 of 214 enrolled patients (20.1%) were AR. ARU levels were significantly higher in patients with recurrence than those without (514[IQR: 466–592] vs. 454[IQR: 411–499]; P Conclusion In conclusion, AR is not uncommon in Chinese stroke patients who receive anti-platelet medications. Patients with AR may have a greater risk of suffering stroke recurrence events.