Regio- and Stereoselective Construction of gamma-Butenolides through Phosphine-Catalyzed Substitution of Morita-Baylis-Hillman Acetates:An Organocatalytic Allylic Alkylation

摘要

The gamma-butenolide ring system ranks among the most ubiquitous structural motifs found in naturally occurring organic molecules.Owing to the prevalence of gamma-butenolides,their regio- and Stereoselective synthesis has been the focus of intensive effort.In this regard,the use of 2-silyloxy furans as nucleophilic partners in Mukaiyama-aldol-,Mukaiyama-Michael-,and Mukaiyama-Mannich-type additions has emerged as an effective strategy.Even broader access to butenolide substructures would be possible through the development of new electrophilic partners amenable to 2-silyloxy furan addition.