How Useful Is Ferrocene as a Scaffold for the Design of beta-Sheet Foldamers?

摘要

The design of structurally well-defined synthetic peptide foldamers is motivated to some degree by the aim to study mechanisms of protein folding or biochemical processes,to generate molecules with potential biological applications,or to generate novel materials.Foldamers adopting beta-sheet-like conformations have held a particular fascination and have tremendous potential as model systems in furthering our understanding of diseases,including Alzheimer's and Huntington's diseases.Non-natural scaffolds have been particularly important for obtaining foldamers with a defined,stable beta-sheet-like structure.