Efficient Trapping of Oxonium Ylides with Imines: A Highly Diastereoselective Three-Component Reaction for the Synthesis of β-Amino-α-hydroxyesters with Quaternary Stereocenters

摘要

Multicomponent reactions are among the most efficient synthetic methods for the construction of organic molecules.[1] This strategy offers significant advantages over classical step-by-step approaches, as it allows the formation of several bonds in a single synthetic operation. Furthermore, in this way complex molecular architectures can be built up from simple precursors without the need for the isolation of intermediates.