...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [ 18F]FPCIT and [ 18F]fallypride
【24h】

Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [ 18F]FPCIT and [ 18F]fallypride

机译：使用[18F] FPCIT和[18F]芳丙烯酸扫描扫描血管扫描血管大鼠大鼠大鼠大鼠大脑中的多巴胺转运蛋白和D2受体的评价

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [ 18F]FPCIT (a dopamine transporter imaging radioligand) and [ 18F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [ 18F]FPCIT was significantly reduced and that of [ 18F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.
机译：本研究的目的是通过双宠物放射性配体研究单侧损伤的6-OHDA大鼠的多巴胺能功能：[18F] FPCIT（多巴胺转运蛋白成像放射性配体）和[18F]芳丙烯键（一种多巴胺D2受体成像放射性配体）。 结果，[18F] Fpcit的脑吸收显着降低，并且在6-OHDA大鼠的同侧纹状体（病变侧）中增加了[18F]芳丙烯丙烯酰胺的脑筋膜。 这些发现涉及到下调多巴胺转运蛋白，并且在该血红蛋白尼斯大鼠模型中上调多巴胺D2受体。

著录项

  • 来源
  • 作者

    ChoiJ.Y.; KimC.H.; JeonT.J.; ChoW.G.; LeeJ.S.; LeeS.J.; ChoiT.H.; KimB.S.; YiC.H.; SeoY.; YiD.I.; HanS.J.; LeeM.; KimD.G.; LeeJ.D.; AnG.; RyuY.H.;

  • 作者单位

    Department of Pharmacology Brain Research Institute Brain Korea 21 Project for Medical Science;

    Department of Pharmacology Brain Research Institute Brain Korea 21 Project for Medical Science;

    Department of Nuclear Medicine Yonsei University College of Medicine Gangnam Severance Hospital;

    Department of Anatomy Yonsei University Wonju College of Medicine Wonju 220-701 South Korea;

    Department of Anatomy Yonsei University Wonju College of Medicine Wonju 220-701 South Korea;

    Department of Anatomy Yonsei University Wonju College of Medicine Wonju 220-701 South Korea;

    Department of Molecular Imaging Korea Institute of Radiological and Medical Sciences Seoul 139;

    Department of Molecular Imaging Korea Institute of Radiological and Medical Sciences Seoul 139;

    Department of Molecular Imaging Korea Institute of Radiological and Medical Sciences Seoul 139;

    Department of Nuclear Medicine Yonsei University College of Medicine Gangnam Severance Hospital;

    Department of Cell Biology and Molecular Genetics University of Maryland College Park MD 20742;

    Department of Molecular Imaging Korea Institute of Radiological and Medical Sciences Seoul 139;

    Department of Nuclear Medicine Yonsei University College of Medicine Gangnam Severance Hospital;

    Department of Pharmacology Brain Research Institute Brain Korea 21 Project for Medical Science;

    Department of Nuclear Medicine Yonsei University College of Medicine Gangnam Severance Hospital;

    Department of Molecular Imaging Korea Institute of Radiological and Medical Sciences Seoul 139;

    Department of Nuclear Medicine Yonsei University College of Medicine Gangnam Severance Hospital;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 原子核物理学、高能物理学 ;
  • 关键词

    6-OHDA; 18Ffallypride; 18FFPCIT; D2R; DAT; MicroPET;

    机译：6-ohhada;[18 f]飞贼;[18 f] false;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号