Selective Excision of C5 from D-Ribose in the Gas Phase by Low-Energy Electrons (0-1 eV):Implications for the Mechanism of DNA Damage

摘要

Sugar is the central unit within a nucleotide connecting the DNA base with the phosphate group,which itself couples to the neighboring nucleotides within single-stranded DNA.The study of the excitation,ionization,and fragmentation of biomolecular systems is essential for the understanding of many problems in the area of life sciences such as the mechanism of radiation damage in cellular systems or the action of radiosensitisers used in tumor therapy.