Cyclosporine increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system

摘要

The discovery of cyclosporin A (CsA) in the 1980s remarkably improved the short-term success rates of transplantation. CD26 [dipeptidylpeptidase IV (DPP IV)] is a membrane-bound extracellular peptidase with the ability to cleave chemokines (11), such as stroma-derived factor-la (SDF-la)/CXC ligand 12 (CXCL12), which serves as a chemoattractant for human CD34~+ cells and stem/progenitor cell populations. Previous reports have demonstrated that immunosuppressed organ transplant patients exhibit lower CD26/DPP IV serum activity compared with healthy individuals (18, 19).