Postconditioning fails to improve no reflow or alter infarct size in an open-chest rabbit model of myocardial ischemia-reperfusion

摘要

two recent clinical studies have suggested that postconditioning (PoC) may have a beneficial effect on the microcirculation after ischemia. A study by Loukogeorgakis and co-workers (17) showed that PoC protected against endothelial injury after forearm ischemia in humans, and Staat et al. (23) reported an improved myocardial blush grade, an estimate of reperfusion at the myocardial level, in humans who received PoC after coronary angioplasty. These studies suggested that PoC may protect against microvascular reperfusion injury.