HIF-1α protein rather than mRNA as a marker of hypoxia in adipose tissue in obesity: focus on “Inflammation is associated with a decrease of lipogenic factors in omental fat in women,” by Poulain-Godefroy et al.

摘要

we were interested to see the article by Poulain-Godefroy et al. (4) in which a global decrease in lipogenic markers was associated with the enhancement of inflammation in human adipose tissue, a relationship accentuated in diabetic subjects. The authors further show that expression levels of the inflammatory markers CD14 and IL-18 are increased in omental compared with subcutaneous adipose tissue, the depot differences being particularly evident for IL-18. This suggests that subcutaneous fat is less susceptible to inflammation than the visceral tissue, consistent with the link between visceral fat and the diseases associated with obesity.