BSA-Bioinspired Gadolinium Hybrid-Functionalized Hollow Gold. Nanoshells for NIRF/PA/CT/MR Quadmodal Diagnostic Imaging Guided Photothermal/Photodynamic Cancer Therapy

摘要

Multimodal imaging guided synergistic therapy promises more accurate diagnosis and higher therapeutic efficiency than single imaging modality or their simple "mechanical" combination. In this research, we fabricated a new multifunctional drug delivery system based on hollow gold nanoshells capped by gadolinium (Gd)-based bovine serum albumin (BSA) hybrids (Au@BSA-Gd). The obtained nanoparticles exhibited excellent photothermal effect and computed tomography (CT)/photoacoustic (PA) activity. Besides, the BSA-bioinspired gadolinium complex endowed the nanoparticles attractive T-1 contrast agent in magnetic resonance imaging (MRI). In addition, the NIR absorbing phototherapeutic agent (ICG) was loaded into the Au@BSA-Gd nanoparticles due to their unique hollow and porous structures, thus performing photodynamic/photothermal property and near-infrared fluorescence (NIRF)/PA imaging capability. In this manner, a combined therapy approach was established consisting of photothermal therapy based on Au@BSA-Gd and photodynamic/photothermal therapy based on ICG. Furthermore, the well-designed nanocomposites with multiple integrated modalities enabled them to be an ideal nanotheranostic agent for NIRF/PA/CT/MR quadmodal imaging. Therefore, the ICG loaded albumin-bioinspired gadolinium hybrids functionalized hollow gold nanoshells (ICG-Au@BSA-Gd) hold great promise as a theranostic platform for simultaneously therapeutic monitoring and precise cancer therapy.