Biomimetic Elastomeric Polypeptide-Based Nanofibrous Matrix for Overcoming Multidrug-Resistant Bacteria and Enhancing Full-Thickness Wound Healing/Skin Regeneration

摘要

Overcoming the multidrug-resistant (MDR) bacterial infection is a challenge and urgently needed in wound healing. Few wound dressings possess the capacity treat MDR bacterial infections and enhance wound healing. Herein, we develop an elastomeric, photo-luminescent, and antibacterial hybrid polypeptide-based nanofibrous matrix as a multifunctional platform to inhibit nanofibrous matrix was composed of poly(citrate)-epsilon-polylysine (PCE) and poly caprolactone (PCL). The PCL-PCE hybrid nanofibrous matrix showed a biomimetic elastomeric behavior, robust antibacterial activity including killing MDR bacteria capacity, and excellent biocompatibility. PCL-PCE nanofibrous system can efficiently prevent the MDR bacteria-derived wound infection and significantly enhance the complete skin-thickness wound healing and skin regeneration in a mouse model. PCL-PCE hybrid nanofibrous matrix might become a competitive multifunctional dressing for bacteria-infected wound healing and skin regeneration.