Chronic Mild Hypoxia Ameliorates Chronic Inflammatory Activity in Myelin Oligodendrocyte Glycoprotein (MOG) Peptide Induced Experimental Autoimmune Encephalomyelitis (EAE)

摘要

Abstract While the pathologic events associated with multiple sclerosis (MS), diffuse axonal injury, cognitive damage, and white matter plaques, have been known for some time, the etiology of MS is still unknown and therapeutic efforts are somewhat disappointing. This may be due to a lack of fundamental knowledge on how to buffer the brain from secondary injury following immune attack. Maintenance of central nervous system (CNS) homeostasis is a complex set of regulatory adjustments by the neurovascular unit that includes induction of adaptive angiogenesis. Although aspects of adaptive angiogenesis are induced in MS and experimental autoimmune encephalomyelitis (EAE), vascular remodeling is ineffective and the balance between metabolic need and oxygen (O2) and glucose availability is disrupted.