Substance p-saporin for bone cancer pain in dogs can man's best friend solve the lost in translation problem in analgesic development?

摘要

In the United States, cancer is the second most common cause of death and over a half million people die from cancer annually. Bone cancer pain is a common cause of pain in patients with advanced cancer and described as a combination of background, dull pain and breakthrough, severe pain (spontaneous and incident pain). Breakthrough pain episodes, often unpredictable, affect many aspects of life, including mood, sleep, and physical and social activities, and are often refractory to conventional therapies, including opioids, nonsteroidal antiinflammatory drugs, bisphos-phonates, and radiotherapy.