Pulsed Electron Deposition of nanostructured bioactive glass coatings for biomedical applications

摘要

Due to poor mechanical properties and brittleness of bioactive glasses, the deposition of bioactive glass coatings on bioinert metallic implants for bone regeneration is a promising route to combine the high bioactivity of the glassy phase with the mechanical strength of metallic substrate. The Pulsed Electron Deposition (PED) technique has been recently demonstrated to be an effective method to fabricate highly-adherent and nanostructured bioactive thin films and coatings, with fine control over film composition. In this paper, we investigated the deposition by PED of 45S5 Bioglass and of a novel CaO-rich bioactive glass, also containing potassium oxide. Composition, microstructure, surface morphology, wettability and adhesion to the titanium substrate were assessed for both as-deposited and annealed coatings. All samples exhibited a nanostructured surface morphology and high hydrophilicity, both positive features for biological applications. In particular, annealed samples exhibited increased roughness and adhesion degree to the titanium substrate compared to the as-deposited ones. The results showed in this paper suggest that bioactive glass coatings deposited by PED are promising for being further investigated as bioactive coatings for bone implants.