Effect of alpha 7n-Acetylcholine Receptor Activation and Antibodies to TNF-alpha on Mortality of Mice and Concentration of Proinflammatory Cytokines During Early Stage of Sepsis

摘要

Experiments on random-bred albino mice showed that activation alpha 7n-acetylcholine receptors with anabasine (0.5 LD50) and the use of antibodies to TNF-alpha (1 mg/kg) 2 h before sepsis modeling significantly reduces mortality of mice from experimental sepsis (intraperitoneal injection of E. coli) due to a decrease in the blood concentration of proinflammatory cytokines TNF-alpha, IL-1 beta, and IL-6. After combined administration of anti-TNF-alpha antibodies and anabasine, an additive effect was observed.