Prognostic relevance of CCAs/Ph- in CML settled

摘要

In this issue of Blood, Issa et al(1) report that patients with chronic-phase chronic myeloid leukemia (CML) in remission after treatment with tyrosine kinase inhibitors (TKIs) with clonal chromosomal aberrations (CCAs) in Philadelphia chromosome-negative (Ph-) metaphases had a significantly worse survival than similar patients without CCAs. This study is notable for the large number of patients with CCAs (n = 58) and the length of follow up (median, 7.6 years) (see figure).