NF-kappaB-induced chromatin remodeling regulates angiogenesis.

摘要

In this issue of Blood, Aurora and colleagues identify a novel mechanism for the inhibition of angiogenesis by PEDF and TSP1, mediated via chromatin remodeling and transcriptional regulation by NF-kappaB. Angiogenesis, formation of new vessels from preexisting ones, occurs both in physiologic and pathologic settings including tumor growth. There is a yet unproven hypothesis that in the physiologic nonangiogenic state, an equilibrium between endogenous antiangiogenic and proangiogenic molecules maintains the "angiogenic balance,