Osteopontin: an unhealthy sleep remedy for ALL.

摘要

Validation of the molecular underpinnings of JMML derived from mouse models,2 has been limited in humans due to a scarcity of primary clinical samples. JMML is a rare childhood leukemia that has nonetheless played a central and highly informative role in clarifying the consequences of Ras hyperactivation in human malignancies as well as in human congenital disorders.3 JMML also continues to be the recipient of intense investigation because its only curative therapy is allogeneic hematopoietic stem cell (HSC) transplantation, and yet 50% of children will succumb to leukemia relapse following this arduous therapy.