Podosomes are disrupted in PAPA syndrome

摘要

In this issue of Blood, Starnes et al describe a novel proline-serine- threonine phosphatase-interacting protein 1 (PSTPIP1) mutation that is responsible for pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome. This helps us understand how PSTPIP1 regulates podosome and filopodia formation and migration of macrophages.