Phase 1 Results from a Phase 1/2 Study to Assess the Safety, Tolerability and Recommended Phase 2 Dose (RP2D) of Brentuximab Vedotin Plus Doxorubicin, Vinblastine and Dacarbazine (A plus AVD) in Pediatric Patients (Pts) with Advanced Stage Newly Diagnosed Classical Hodgkin Lymphoma (cHL)

Franklin Anna; Zecca Marco; Fagioli Franca; Luisi Flavio Augusto; Song Gregory; Suri Ajit; Leonard E. Jane; Locatelli Franco

首页> 外文期刊>Blood: The Journal of the American Society of Hematology >Phase 1 Results from a Phase 1/2 Study to Assess the Safety, Tolerability and Recommended Phase 2 Dose (RP2D) of Brentuximab Vedotin Plus Doxorubicin, Vinblastine and Dacarbazine (A plus AVD) in Pediatric Patients (Pts) with Advanced Stage Newly Diagnosed Classical Hodgkin Lymphoma (cHL)

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Phase 1 Results from a Phase 1/2 Study to Assess the Safety, Tolerability and Recommended Phase 2 Dose (RP2D) of Brentuximab Vedotin Plus Doxorubicin, Vinblastine and Dacarbazine (A plus AVD) in Pediatric Patients (Pts) with Advanced Stage Newly Diagnosed Classical Hodgkin Lymphoma (cHL)

机译：1/2期的第1阶段结果，以评估小儿患者（PTS）中布伦克西非葡萄球菌，长霉素和达卡巴嗪（A加AVD）的安全性，耐受性和推荐2剂量（RP2D），具有新诊断的经典的晚期阶段 Hodgkin淋巴瘤（CHL）

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来源
《Blood: The Journal of the American Society of Hematology》 |2018年第novaelatreatmentappr期|共2页
作者
Franklin Anna; Zecca Marco; Fagioli Franca; Luisi Flavio Augusto; Song Gregory; Suri Ajit; Leonard E. Jane; Locatelli Franco;
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作者单位

Childrens Hosp Colorado Ctr Canc &

Blood Disorders Aurora CO USA;

Fdn IRCCS Policlin San Matteo Pediat Hematol Oncol Pavia Italy;

Univ Turin Childrens Hosp Regina Margherita Turin Italy;

Grp Apoio Ao Adolescente &

Crianca Com Canc Sao Paulo Brazil;

Millennium Pharmaceut Inc Cambridge MA USA;

Millennium Pharmaceut Inc Cambridge MA USA;

Millennium Pharmaceut Inc Cambridge MA USA;

IRCCS Osped Pediat Bambino Gesu Dept Pediat Hematol Oncol &

Cell &

Gene Therapy Rome Italy;

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正文语种 eng
中图分类血液及淋巴系疾病;
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1. Phase 1 Results from a Phase 1/2 Study to Assess the Safety, Tolerability and Recommended Phase 2 Dose (RP2D) of Brentuximab Vedotin Plus Doxorubicin, Vinblastine and Dacarbazine (A plus AVD) in Pediatric Patients (Pts) with Advanced Stage Newly Diagnosed Classical Hodgkin Lymphoma (cHL) [J] . Franklin Anna, Zecca Marco, Fagioli Franca, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：1/2期的第1阶段结果，以评估小儿患者（PTS）中布伦克西非葡萄球菌，长霉素和达卡巴嗪（A加AVD）的安全性，耐受性和推荐2剂量（RP2D），具有新诊断的经典的晚期阶段 Hodgkin淋巴瘤（CHL）
2. Brentuximab vedotin combined with ABVD or AVD for patients with newly diagnosed Hodgkin's lymphoma: A phase 1, open-label, dose-escalation study [J] . YounesA., ConnorsJ.M., ParkS.I., The lancet oncology . 2013,第13期

机译：Brentuximab vedotin联合ABVD或AVD用于新诊断霍奇金淋巴瘤的患者：A期1，开放标签，剂量递增研究
3. Phase II study of ABV (doxorubicin with increased dose, bleomycin and vinblastine) therapy in newly diagnosed advanced-stage Hodgkin lymphoma: Japan Clinical Oncology Group study (JCOG9705) [J] . OguraM., ItohK., IshizawaK., Leukemia and lymphoma . 2013,第1期

机译：在新诊断的晚期霍奇金淋巴瘤中进行ABV（阿霉素，增加剂量的博来霉素和长春碱）治疗的II期研究：日本临床肿瘤学小组研究（JCOG9705）
4. Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin Vinblastine and Dacarbazine (BV+AVD) [O] . Yasunobu Sekiguchi, Hiroko Iizuka, Haruko Takizawa, 2020

机译：甲氨蝶呤相关的霍格金淋巴瘤在患者中用风湿性关节炎与Brentuximab Vedotin联合与多柔比星长霉素和达卡巴嗪（BV + AVD）组合治疗
5. AN OPEN‐LABEL, PHASE 1/2 STUDY OF FRONTLINE BRENTUXIMAB VEDOTIN + ADRIAMYCIN, VINBLASTINE, AND DACARBAZINE IN PAEDIATRIC PATIENTS WITH ADVANCED STAGE HODGKIN LYMPHOMA [O] . A.R.K Franklin, F. A. V Luisi, M. A Pianovski, 2021

机译：前期Brentuximab Vedotin + Adriamycin，Chinblastine和Dacarbazine的开放标签，阶段1/2研究高级霍格金淋巴瘤的儿科患者

Phase 1 Results from a Phase 1/2 Study to Assess the Safety, Tolerability and Recommended Phase 2 Dose (RP2D) of Brentuximab Vedotin Plus Doxorubicin, Vinblastine and Dacarbazine (A plus AVD) in Pediatric Patients (Pts) with Advanced Stage Newly Diagnosed Classical Hodgkin Lymphoma (cHL)

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