Intravenous Administration of Recombinant Factor VIII Induces Immune Tolerance to Subcutaneous Turoctocog Alfa Pegol (SC N8-GP) in Humanized Hemophilia A Mice

Reedtz-Runge Stine Louise; Weldingh Karin; Schultz Heidi Schioler; Millner Anders Holm; Rode Frederik; Wiinberg Bo; Kjelgaard-Hansen Mads

首页> 外文期刊>Blood: The Journal of the American Society of Hematology >Intravenous Administration of Recombinant Factor VIII Induces Immune Tolerance to Subcutaneous Turoctocog Alfa Pegol (SC N8-GP) in Humanized Hemophilia A Mice

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Intravenous Administration of Recombinant Factor VIII Induces Immune Tolerance to Subcutaneous Turoctocog Alfa Pegol (SC N8-GP) in Humanized Hemophilia A Mice

机译：重组因子VIII的静脉内给药诱导人源化血友病中的皮下Turoctocog Alfa Pegol（SC N8-GP）的免疫耐受性

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来源
《Blood: The Journal of the American Society of Hematology》 |2018年第novaelatreatmentappr期|共2页
作者
Reedtz-Runge Stine Louise; Weldingh Karin; Schultz Heidi Schioler; Millner Anders Holm; Rode Frederik; Wiinberg Bo; Kjelgaard-Hansen Mads;
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Novo Nordisk AS Global Drug Discovery Malov Denmark;

Novo Nordisk AS Global Drug Discovery Malov Denmark;

Novo Nordisk AS Global Drug Discovery Malov Denmark;

Novo Nordisk AS Global Drug Discovery Malov Denmark;

Novo Nordisk AS Global Drug Discovery Malov Denmark;

Novo Nordisk AS Global Drug Discovery Malov Denmark;

Novo Nordisk AS Global Drug Discovery Malov Denmark;

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原文格式 PDF
正文语种 eng
中图分类血液及淋巴系疾病;
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1. Intravenous Administration of Recombinant Factor VIII Induces Immune Tolerance to Subcutaneous Turoctocog Alfa Pegol (SC N8-GP) in Humanized Hemophilia A Mice [J] . Reedtz-Runge Stine Louise, Weldingh Karin, Schultz Heidi Schioler, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：重组因子VIII的静脉内给药诱导人源化血友病中的皮下Turoctocog Alfa Pegol（SC N8-GP）的免疫耐受性
2. Continuous infusions of B domain-truncated recombinant factor VIII, turoctocog alfa, for orthopedic surgery in severe hemophilia A: first case report [J] . Masahiro Takeyama, Keiji Nogami, Ryohei Kobayashi, International journal of hematology . 2018,第2期

机译：B域截短的重组因子VIII，Turoctocog Alfa的连续输注，用于严重血友病的矫形手术A：第一个案例报告
3. The pharmacokinetics of a B-domain truncated recombinant factor VIII, turoctocog alfa (NovoEight (R)), in patients with hemophilia A [J] . Jimenez-Yuste V., Lejniece S., Klamroth R., Journal of thrombosis and haemostasis: JTH . 2015,第3期

机译：B结构域截短的重组因子VIII turoctocog alfa（NovoEight（R））在血友病A患者中的药代动力学
4. Phosphatidylinositol reduces the immunogenicity and clearance of human recombinant factor VIII in hemophilia a mice. [D] . Peng, Aaron. 2011

机译：磷脂酰肌醇降低了血友病a小鼠中人重组因子VIII的免疫原性和清除率。
5. Health-related quality-of-life and treatment satisfaction of individuals with hemophilia A treated with turoctocog alfa pegol (N8-GP): a new recombinant extended half-life FVIII [O] . Susan Kearney, Leslie J Raffini, Tan P Pham, 2019

机译：用图坦古柯阿尔法聚乙二醇（N8-GP）治疗的血友病A患者的健康相关生活质量和治疗满意度：新型重组延长的半衰期FVIII
6. Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice [O] . Krishnamoorthy Sriram, Liu Tongyao, Drager Douglas, 2016

机译：重组凝血因子VIII Fc（rFVIIIFc）融合蛋白可降低A型血友病小鼠的免疫原性并诱导其耐受性

Intravenous Administration of Recombinant Factor VIII Induces Immune Tolerance to Subcutaneous Turoctocog Alfa Pegol (SC N8-GP) in Humanized Hemophilia A Mice

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