A Next-Generation Fc-Bearing CD3-Engaging Bispecific DART (R) Platform with Extended Pharmacokinetic and Expanded Pharmacologic Window: Expanded CD123 x CD3 and CD19 x CD3 DART Molecules

Bonvini Ezio; La Motte-Mohs Ross; Huang Ling; Lam Chia-Ying Kao; Kaufman Thomas; Liu Liqin; Alderson Ralph F.; Stahl Kurt; Brown Jennifer G.; Li Hua; Sharma Sharad; Tamura James; Johnson Syd; Moore Paul

首页> 外文期刊>Blood: The Journal of the American Society of Hematology >A Next-Generation Fc-Bearing CD3-Engaging Bispecific DART (R) Platform with Extended Pharmacokinetic and Expanded Pharmacologic Window: Expanded CD123 x CD3 and CD19 x CD3 DART Molecules

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A Next-Generation Fc-Bearing CD3-Engaging Bispecific DART (R) Platform with Extended Pharmacokinetic and Expanded Pharmacologic Window: Expanded CD123 x CD3 and CD19 x CD3 DART Molecules

机译：具有扩展药代动力学和扩展药物窗口的下一代FC-轴承CD3 - 接合双特异性达特（R）平台：扩展CD123 X CD3和CD19 X CD3 Dart分子

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来源
《Blood: The Journal of the American Society of Hematology》 |2018年第novaelatreatmentappr期|共2页
作者
Bonvini Ezio; La Motte-Mohs Ross; Huang Ling; Lam Chia-Ying Kao; Kaufman Thomas; Liu Liqin; Alderson Ralph F.; Stahl Kurt; Brown Jennifer G.; Li Hua; Sharma Sharad; Tamura James; Johnson Syd; Moore Paul;
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MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Brisbane CA USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

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原文格式 PDF
正文语种 eng
中图分类血液及淋巴系疾病;
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1. A Next-Generation Fc-Bearing CD3-Engaging Bispecific DART (R) Platform with Extended Pharmacokinetic and Expanded Pharmacologic Window: Expanded CD123 x CD3 and CD19 x CD3 DART Molecules [J] . Bonvini Ezio, La Motte-Mohs Ross, Huang Ling, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：具有扩展药代动力学和扩展药物窗口的下一代FC-轴承CD3 - 接合双特异性达特（R）平台：扩展CD123 X CD3和CD19 X CD3 Dart分子
2. Adaptive Immune Gene Signatures Correlate with Response to Flotetuzumab, a CD123 X CD3 Bispecific Dart (R) Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia [J] . Rutella Sergio, Church Sarah E., Vadakekolathu Jayakumar, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：自适应免疫基因签名与对FloteTuzumab的反应相关，CD123 X CD3双特异性镖（R）分子，复发/难治性急性髓性白血病患者
3. Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity [J] . Campagne Olivia, Delmas Audrey, Fouliard Sylvain, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第11期

机译：非特异性CD3XCD123 Dart分子的综合药代动力学/药效学模型在非人的灵长类动物中：免疫原性的影响和影响的评价
4. The expanded CD19~+IgM~+CD27CD21~(low)CD38~(low)CD24B cell population in CVID patients shows the signs of antigen-driven selection and affinity maturation [C] . Novakova Lucie, Vlkova Marcela, Kalina Tomas, European Congress of Immunology . 2009

机译：CVID患者CD27CD21〜（低）CD24B细胞群（低）CD24B细胞群表现出抗原驱动的选择和亲和力成熟的迹象
5. Comparative pharmacology of the human CD19/CD3 Bispecific T-cell engager (BiTERTM) antibody blinatumomab with the hybrid murine surrogate CD19/CD3 BiTE antibody hyS103. [D] . Fuhrmann, Stacy R. 2010

机译：人CD19 / CD3双特异性T细胞衔接子（BiTERTM）抗体blinatumomab与杂种鼠替代CD19 / CD3 BiTE抗体hyS103的比较药理学。
6. Development of PF-06671008 a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer [O] . Adam R. Root, Wei Cao, Bilian Li, 2016

机译：PF-06671008的开发一种高强度的抗P-钙粘蛋白/抗CD3双特异性DART分子具有延长的半衰期可用于治疗癌症
7. Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity [O] . Olivia Campagne, Audrey Delmas, Sylvain Fouliard, 2018

机译：非特异性CD3XCD123 Dart分子的综合药代动力学/药效学模型在非人的灵长类动物中：免疫原性的影响和影响的评价

A Next-Generation Fc-Bearing CD3-Engaging Bispecific DART (R) Platform with Extended Pharmacokinetic and Expanded Pharmacologic Window: Expanded CD123 x CD3 and CD19 x CD3 DART Molecules

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