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首页> 外文期刊>Biochemistry >Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027
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Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

机译:在Enediyne抗肿瘤抗生素C-1027的生物合成中,对独立凝结酶SGCC5催化酯 - 键形成的结构见解

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摘要

机译:<![CDATA [C-1027是一种抗蛋白酶抗肿瘤抗生素,由CAGA凋亡和C-1027发色团组成。 C-1027发色团具有含有三个外周部分的九元肌核心,包括( S)-3-氯-5-羟基-β-酪氨酸和( r)-1-苯基-1,2-乙二醇酸碱催化作用。这些发现扩展了催化曲目,并揭示了缩合酶结构和机制的新见解。]]>

著录项

  • 来源
    《Biochemistry》 |2018年第23期|共11页
  • 作者单位

    Department of Chemistry The Scripps Research Institute Jupiter;

    Department of Chemistry The Scripps Research Institute Jupiter;

    Department of Chemistry The Scripps Research Institute Jupiter;

    Midwest Center for Structural Genomics Biosciences Division Argonne National Laboratory;

    Midwest Center for Structural Genomics Biosciences Division Argonne National Laboratory;

    Department of Chemistry The Scripps Research Institute Jupiter;

    Midwest Center for Structural Genomics Biosciences Division Argonne National Laboratory;

    Department of Chemistry The Scripps Research Institute Jupiter;

    Department of Chemistry The Scripps Research Institute Jupiter;

    Midwest Center for Structural Genomics Biosciences Division Argonne National Laboratory;

    Midwest Center for Structural Genomics Biosciences Division Argonne National Laboratory;

    BioSciences at Rice and Department of Chemistry Rice University;

    Department of Chemistry The Scripps Research Institute Jupiter;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

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