A NEW X A NTH ONE AND ANTI-INFLAMMATORY CONSTITUENTS OF G arc in i a suhelliptica

摘要

A new xanthone, garcisnbellnne (I), has been isolated from the roots of Garcinia suhelliptica, together with three known compounds, subelliptenone K (2), 1.5-dihydroxy-3-methoxyxanthone (3). and 1,4,5-trihydroxyxanthone (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Garcisubellonc (1) and 1,4,5-trihydroxyxanthone (4) exhibited potent inhibition, with IC3(, values of 18.3 ± 2.2 and 15.6 ± 2.8 uM, respectively, against formyl-L-methionyl-L-leueyl-L-phenylalanine (fMLP)-indueed superoxide anion (O2~-) generation.