Synthesis and in vitro evaluation of thiododecaborated α, α-cycloalkylamino acids for the treatment of malignant brain tumors by boron neutron capture therapy

摘要

Boron-neutron capture therapy (BNCT) is an attractive technique for cancer treatment. As such, a, α-cyeloalkyl amino acids containing thiododecaborate ([B_(12)H_(11)]~(2-)-S-) units were designed and synthesized as novel boron delivery agents for BNCT. In the present study, new thiododecaborate α, α-cycloalkyl amino acids were synthesized, and biological evaluation of the boron compounds as boron carrier for BNCT was carried out.