THE ARTICLE "ANGLE-CLOSURE GLAUCOMA-SIMPLER AN-swers to complex mechanisms: LXVI Edward Jackson Memorial Lecture" by Harry A Quigley1 introduces a new concept of dynamic physiological features precipitating acute angle closure in susceptible individuals with static anatomic factors. This answers many issues related to the pathogenesis of glaucoma in general and angle-closure glaucoma in particular.The possible mechanism of reduced exchange of extracellular fluid with the aqueous as suggested by Quigley, citing the difference in iris connective tissue histologic studies in angle-closure eyes, is understandable in diseased eyes. In eyes affected by acute angle closure, the damage caused by acute rise in intraocular pressure (IOP) results in higher density of collagen in the stromal tissue and damage to the stroma.
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机译：哈里·阿奎格利（Harry A Quigley）1撰写的文章“对复杂机制的角度闭合性青光眼-简明扼要的人：LXVI爱德华·杰克逊纪念堂演讲”介绍了动态生理特征的新概念，该概念使易受影响的具有静态解剖学因素的个体能够急性闭合角度。这回答了许多与一般青光眼的发病有关的问题，特别是与闭角型青光眼有关的问题.Quigley提出了减少细胞外液与房水交换的可能机制，并引用了闭角型虹膜结缔组织组织学研究的差异。眼睛，在患病的眼睛中是可以理解的。在受锐角闭合影响的眼睛中，眼内压（IOP）急剧升高引起的损伤导致基质组织中胶原蛋白的密度更高，并损害基质。
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