Magnetic silica nanoparticle-supported copper complex as an efficient catalyst for the synthesis of novel triazolopyrazinylacetamides with improved antibacterial activity

摘要

A novel superparamagnetic iron oxide modified with copper via 2-aminobenzamide is synthesized by the modification of Fe_3O_4@SiO_2 with amine, followed by the reaction with isatoic anhydride.The catalyst is fully characterized by various methods.The catalytic activity of the catalyst is evaluated in the synthesis of a series of novel N-alkyl-2-aryl-2-(6-oxo-6,7-dihydro[1,2,3]triazolo[ 1,5-a]pyrazin-5(4H)-yl)acetamide analogs.Antibacterial activity of the synthesized compounds is evaluated.The catalyst is recoverable and shows excellent reusability in 10 sequential runs.