Posttransplant lymphoproliferative disorders: A continued threat for kidney transplant recipients

摘要

Lymphoid neoplasia continues to pose a serious problem for immunosuppressed recipients of solid organ transplants. Previous studies, derived mostly from analyses of registry data, suggest that posttransplant lymphoma occurs in l%-2% of kidney transplant recipients, translating to a risk that is 10- to 20-fold higher than that in the general population. Over 90% of cases of posttransplant lymphoma have been linked to proliferation of Epstein-Barr virus (EBV)-infected B cells resulting from suppression of normal immune surveillance by immunosuppressive therapy.