Anti-gastritic Action of Artichoke Leaf Extract Mediated by Endogenous Prostaglangins

摘要

The present study was designed to clarify whether the anti-gastritic and gastric mucus-increasing actions of artichoke leaf extract are mediated by endogenous prostaglandins (PGs) or not. Aspirin at 50 and 100 mg/kg, i.p. inhibited prostaglandin E_2 (PGE2) content in gastric mucosa at 3 h by 80% with no gastric mucosal injury in rats. Artichoke leaf extract at 250 mg/kg, p.o. and cynaropicrin, the main component, at 2.5 mg/kg, p.o. markedly inhibited absolute ethanol-induced gastric mucosal injury in rats by 85% and 96%, respectively in rats. In addition, artichoke leaf extract at 1500 mg/kg, p.o. and cynaropicrin at 15 mg/kg, p.o. markedly prevented restraint plus water immersion stress-induced gastric mucosal injury by 98% and 96%, respectively, in rats. Artichoke leaf extract at 1000 mg/kg, p.o. and cynaropicrin at 10 mg/kg, p.o. markedly increased the gastric mucus content in normal rats by 62% and 52%, respectively. However, anti-gastritic and gastric mucus-increasing actions of both materials were markedly decreased or disappeared completely by pretreatment with i.p. asprin (50 or 100 mg/kg). Artichoke leaf extract (500, 1000 and 2000 mg/kg, p.o.) and cynaropicrin (5, 10 and 20 mg/kg, p.o.) dose-dependently increased in gastric mucosal PGE_2 and cAMP contents in normal rats. These results suggest strongly that the anti-gastritic and gastric mucus-increasing actions of artichoke leaf extract and cynaropicrin may be mainly due to the increase in the biosynthesis of prostaglandins such as PGE_2 in gastric mucosa.