プリンゾラミド2回点眼からプリンゾラミド,ドルゾラミド3回点眼への変更による眼圧下降効果

摘要

Purpose : To compare the effect of topical brinzolamide and dorzolamide thrice daily. Cases and Method : This study was made on 28 eyes of 28 patients who had been receiving latanoprost and brinzolamide twice daily for primary open-angle glaucoma. In 15 patients, brinzolamide was increased from twice to thrice daily. In 13 patients, brinzolamide was switched to 1 % dorzolamide thrice daily. Latanoprost was continued in both groups. Intraocular pressure (IOP) was monitored for 3 months after switching. Results : Three months after switching, IOP in 15 eyes receiving brinzolamide decreased by an average of 1.2 mmHg (p < 0.0001). In 13 eyes receiving dorzolamide, IOP decreased by an average of 1.2 mmHg (p < 0.01). Conclusion : Instillation of brinzolamide thrice daily or dorzolamide thrice daily has greater hypotensive effect for primary open-angle glaucoma than brinzolamide twice daily.