The effects of treatment-resistant depression and first-ever depression on mortality following acute coronary syndrome: interactive or independent?

摘要

To the Editor: Drs. Carney and Freedland (1) presented a fascinating review on treatment-resistant depression and mortality following acute coronary syndrome. As a possible mechanism explaining the association between treatment-resistant depression and mortality in acute coronary syndrome patients, the authors suggested the presence of first-ever depressive episodes, which are associated with both treatment resistance and increased risk of cardiac events.