A new actin-binding area of the myosin light chains' high-molecular kinase

摘要

High-molecular weight isoform of myosin light chain kinase (MLCK-210) contains a unique N-terminal domain not present in a low-molecular weight isoform, MLCK-108. Functional features of this domain are poorly studied. We provide evidence that N-terminal area of the unique MLCK-210 domain incorporates previously unrecognized actin-binding region that could be involved in the interaction of MLCK-210 with the actin cytoskeleton.