Assessment of pre‐operative maropitant citrate use in macaque (        <i >Macaca fasicularis & Macaca mulatta)Macaca fasicularis & Macaca mulatta)        neurosurgical procedures

Steinbach Jaclyn R.; MacGuire Jamus; Chang Shu; Dierks Elizabeth; Roble Gordon S.

摘要

Abstract <section numbered="no" xml:id="jmp12343-sec-0001"> <title type="main">Background > Retrospective analysis of post‐operative vomiting ( <fc>POV</fc> ) in non‐human primates at our institution was 11%. Based on this additional risk factor for post‐operative complications, we aimed to eliminate or decrease <fc>POV</fc> by adding an antiemetic, maropitant citrate, to the pre‐medication protocol. </section> <section numbered="no" xml:id="jmp12343-sec-0002"> <title type="main">Methods > Retrospective and prospective data were collected over a 5‐year period from 46 macaques of two species during 155 procedures. Additionally, blood was collected from five Macaca mulatta to perform a pharmacokinetic analysis. </section> <section numbered="no" xml:id="jmp12343-sec-0003"> <title type="main">Results > A 1?mg/kg subcutaneous dose of maropitant given pre‐operatively significantly decreased <fc>POV</fc> . Findings indicated post‐neurosurgical emesis in Macaca fasicularis was significantly greater than in Macaca mulatta . Pharmacokinetic analysis of maropitant in Macaca mulatta determined the mean maximum plasma concentration to be 113?ng/mL. </section> <section numbered="no" xml:id="jmp12343-sec-0004"> <title type="main">Conclusions > Maropitant administration prior to anesthesia for neurosurgeries decreased our incidence of <fc>POV</fc> to 1%. The plasma concentration reaches the proposed plasma level for clinical efficacy a </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“JMP12343-ABS-ABS-0001”XML：lang =“en”> <标题类型=“main”>抽象</ title> <secueded =“no”xml：id = “JMP12343-SEC-0001”> <标题类型=“main”>背景</ title> >在我们机构的非人类灵长类动物中的术后呕吐（<fc> pov </ fc>）的回顾分析11％。基于这种额外的患者并发症的危险因素，我们旨在通过将止吐剂柠檬酸盐添加到预防疗法方案中来消除或减少<FC> POV>。 </ p> </ section> <部分编号=“否”XML：ID =“JMP12343-SEC-0002”> <标题类型=“main”>方法</ title> >追溯和预期数据在155个程序期间，从两种物种的46个猕猴的5年期。另外，从五个麦卡拉混血菌</ i>收集血液以进行药代动力学分析。 </ p> </ section> <部分编号=“否”XML：ID =“JMP12343-SEC-0003”> <标题类型=“main”>结果</标题> > a 1？mg / kg皮下给予预先可操作地显着降低的疗程的剂量<FC> POV>。在猕猴属中显示出神经外科的发现显着大于麦卡拉混血菌</ i>。在 Macaca mulatta的疗程的药代动力学分析确定平均最大等离子体浓度为113〜ng / ml。 </ p> </段> <部分编号=“否”XML：ID =“JMP12343-SEC-0004”> <标题类型=“MAIN”>结论</标题> >神经诊疗前麻醉前的疗程给药降低了我们<fc> pov>至1％的发病率。血浆浓度达到临床疗效A的提出的等离子体水平 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Steinbach Jaclyn R.&option=202" target="_blank" rel="nofollow">Steinbach Jaclyn R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=MacGuire Jamus&option=202" target="_blank" rel="nofollow">MacGuire Jamus;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chang Shu&option=202" target="_blank" rel="nofollow">Chang Shu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dierks Elizabeth&option=202" target="_blank" rel="nofollow">Dierks Elizabeth;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Roble Gordon S.&option=202" target="_blank" rel="nofollow">Roble Gordon S.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>NYU‐Regeneron Postdoctoral Training Program in Laboratory Animal MedicineNYU Langone HealthNew York NY USA;</p> <p>Veterinary SciencesBristol‐Myers SquibbPrinceton NJ USA;</p> <p>Pharmaceutical Candidate OptimizationBristol‐Myers SquibbPrinceton NJ USA;</p> <p>Pharmaceutical Candidate OptimizationBristol‐Myers SquibbPrinceton NJ USA;</p> <p>NYU‐Regeneron Postdoctoral Training Program in Laboratory Animal MedicineNYU Langone HealthNew York NY USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cerenia&option=203" rel="nofollow">cerenia;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=maropitant citrate&option=203" rel="nofollow">maropitant citrate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=neurosurgery&option=203" rel="nofollow">neurosurgery;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nonhuman primate&option=203" rel="nofollow">nonhuman primate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=post‐operative vomiting&option=203" rel="nofollow">post‐operative vomiting;</a> </p> <div class="translation"> 机译：Cerenia;疗程柠檬酸盐;神经外科;非人类灵长类动物;术后呕吐; 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href="/patent-detail/06120100203721.html">猕猴桃棚架和猕猴桃嫁接评估系统及其方法</a> <b>[P]</b> . <span> 中国专利： CN109463150A </span> <span> . 2019-03-15</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120203871365.html">用于猕猴桃栽培装置的用于猕猴桃栽培装置的猕猴桃搭架</a> <b>[P]</b> . <span> 中国专利： CN203872696U </span> <span> . 2014.10.15</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130438002640.html">DNA molecules encoding <I>Macaca mulatta </I>androgen receptor</a> <b>[P]</b> . <span> 外国专利：  US7060463B2 </span> <span> . 2006-06-13</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：编码<I>猕猴</ I>雄激素受体的DNA分子 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130439563585.html">DNA MOLECULES ENCODING MACACA MULATTA ANDROGEN RECEPTOR</a> <b>[P]</b> . <span> 外国专利：  EP1392821A4 </span> <span> . 2005-01-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：编码马卡达穆拉塔雄激素受体的DNA分子 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130441796216.html">DNA MOLECULES ENCODING MACACA MULATTA ANDROGEN RECEPTOR</a> <b>[P]</b> . <span> 外国专利：  EP1392821A1 </span> <span> . 2004-03-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：编码马卡达穆拉塔雄激素受体的DNA分子 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > 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Assessment of pre‐operative maropitant citrate use in macaque ( Macaca fasicularis & Macaca mulatta)Macaca fasicularis & Macaca mulatta) neurosurgical procedures

摘要