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Uremic encephalopathy in a rhesus macaque ( Macaca mulattaMacaca mulatta ): A case report and a brief review of the veterinary literature

机译：在恒河猴中的尿毒症脑病（麦卡卡mulatta 麦卡拉海麦）：案例报告和对兽医文献的简要审查

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Abstract <section numbered="no" xml:id="jmp12348-sec-0001"> <title type="main">Background > Uremic encephalopathy is uncommon yet is one of the most severe complications of renal failure. We present a case of acute renal failure and associated cerebral and vascular lesions consistent with uremic encephalopathy in a rhesus macaque ( Macaca mulatta ). </section> <section numbered="no" xml:id="jmp12348-sec-0002"> <title type="main">Methods >A 14‐year‐old, female, specific‐pathogen‐free rhesus macaque presented in lateral recumbency, obtunded, severely dehydrated, and hypothermic, with severe azotemia, mild hyponatremia, hypokalemia, hypochloremia, increased anion gap, and hypercholesterolemia. Due to poor prognosis, the animal was euthanized and a complete necropsy was conducted. </section> <section numbered="no" xml:id="jmp12348-sec-0003"> <title type="main">Results >The animal had diffuse proximal renal tubular epithelial necrosis and loss; regeneration of tubular epithelium was not observed. There was bilateral necrosis and loss of neurons and glial cells in the hippocampus and deep cerebral cortex with edema and multifocal areas of hemorrhage. </section> <section numbered="no" xml:id="jmp12348-sec-0004"> <title type="main">Conclusion >We present the first reported case of uremic encephalopathy in a rhesus macaque and describe the associated cerebral and vascular lesions. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“JMP12348-ABS-ABS-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> <secubyed =“no”xml：id = “JMP12348-SEC-0001”> <标题类型=“MAIN”>背景</标题> >尿毒性脑病罕见尚不常见，尚未成为肾功能衰竭最严重的并发症之一。我们提出了一种急性肾功能衰竭和相关的脑病和血管病变，与恒河猴（麦卡拉混血菌</ i）中的尿毒症脑病一致。 </ p> </ section> <secto numbyed =“no”xml：id =“jmp12348-sec-0002”> <标题类型=“main”>方法</ title> >一个14岁，女性，无病原体的恒河猴呈横向闭腹，耐血液，严重脱水和低温，具有严重的氮杂血症，轻度低钠血症，低血症，低血症，阴离子间隙和高胆固醇血症。由于预后差，动物被安乐死，进行了完整的尸检。</ p> </截面> <secteneded =“no”xml：id =“jmp12348-sec-0003”> <标题类型=“main” >结果</标题> >动物具有弥漫性近端肾小管上皮坏死和损失;未观察到管状上皮的再生。在海马和海马和深层脑皮层中有双侧坏死和神经元和胶质细胞的丧失，水肿和出血多焦点。</ p> </段> <截面编号=“否”XML：ID =“JMP12348-SEC- 0004“> <标题类型=”main“>结论</标题> >我们在恒河猴中提出了第一个报告的尿毒症脑病病例，并描述了相关的脑和血管病变。</ p> </段> < /摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mustonen Allison&option=202" target="_blank" rel="nofollow">Mustonen Allison;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gonzalez Olga&option=202" target="_blank" rel="nofollow">Gonzalez Olga;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mendoza Elda&option=202" target="_blank" rel="nofollow">Mendoza Elda;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kumar Shyamesh&option=202" target="_blank" rel="nofollow">Kumar Shyamesh;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dick Edward J.&option=202" target="_blank" rel="nofollow">Dick Edward J.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio TX USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=acute kidney injury&option=203" rel="nofollow">acute kidney injury;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=brain diseases&option=203" rel="nofollow">brain diseases;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=renal insufficiency&option=203" rel="nofollow">renal insufficiency;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=uremia&option=203" rel="nofollow">uremia;</a> </p> <div class="translation"> 机译：急性肾损伤;脑病;肾功能不全;尿毒症; 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