Dodecafluoropentane Emulsion in Acute Ischemic Stroke: A Phase Ib/II Randomized and Controlled Dose-Escalation Trial

Culp William C.; Onteddu Sanjeeva S.; Brown Aliza; Nalleballe Krishna; Sharma Rohan; Skinner Robert D.; Witt Taylor; Roberson Paula K.; Marsh James D.

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Dodecafluoropentane Emulsion in Acute Ischemic Stroke: A Phase Ib/II Randomized and Controlled Dose-Escalation Trial

机译：十二烷氟戊烷乳液在急性缺血性中风中：A相IB / II随机和受控剂量 - 升级试验

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Purpose: This randomized, placebo-controlled, double-blind, dose-escalation acute ischemic stroke trial was designed to demonstrate maximum tolerated dose, characterize adverse events (AEs), and explore clinical outcomes when intravenous dodecafluoropentane emulsion (DDFPe) was used as neuroprotection.

机译：目的：这种随机，安慰剂控制，双盲剂剂量升级急性缺血性脑卒中试验旨在证明最大耐受剂量，表征不良事件（AES），并在静脉内十二烷氟丙烷乳液（DDFPE）作为神经保护时探讨临床结果。

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《Journal of vascular and interventional radiology: JVIR 》 |2019年第8期| 共7页
作者
Culp William C.; Onteddu Sanjeeva S.; Brown Aliza; Nalleballe Krishna; Sharma Rohan; Skinner Robert D.; Witt Taylor; Roberson Paula K.; Marsh James D.;
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Univ Arkansas Med Sci Dept Radiol 4301 West Markham St Little Rock AR 72205 USA;

Univ Arkansas Med Sci Dept Neurol 4301 West Markham St Little Rock AR 72205 USA;

Univ Arkansas Med Sci Dept Radiol 4301 West Markham St Little Rock AR 72205 USA;

Univ Arkansas Med Sci Dept Neurol 4301 West Markham St Little Rock AR 72205 USA;

Univ Arkansas Med Sci Dept Radiol 4301 West Markham St Little Rock AR 72205 USA;

Univ Arkansas Med Sci Dept Neurol 4301 West Markham St Little Rock AR 72205 USA;

Univ Arkansas Med Sci Dept Radiol 4301 West Markham St Little Rock AR 72205 USA;

Univ Arkansas Med Sci Dept Biostat 4301 West Markham St Little Rock AR 72205 USA;

Univ Arkansas Med Sci Dept Internal Med 4301 West Markham St Little Rock AR 72205 USA;

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正文语种 eng
中图分类放射医学 ;
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1. Dodecafluoropentane Emulsion in Acute Ischemic Stroke: A Phase Ib/II Randomized and Controlled Dose-Escalation Trial [J] . Culp William C., Onteddu Sanjeeva S., Brown Aliza, Journal of vascular and interventional radiology: JVIR . 2019 ,第8期

机译：十二烷氟戊烷乳液在急性缺血性中风中：A相IB / II随机和受控剂量 - 升级试验
2. Human urinary kallidinogenase in treating acute ischemic stroke patients: analyses of pooled data from a randomized double-blind placebo-controlled phase IIb and phase III clinical trial [J] . Dong Yi, Qu Jiazhi, Zhang Zhijun, Neurological Research: An Interdisciplinary Quarterly Journal . 2020 ,第4期

机译：治疗急性缺血性脑卒中患者的人泌尿基因酶：来自随机双盲安慰剂控制IIB和第III期临床试验的合并数据分析
3. The Impact of Rehabilitation-oriented Virtual Reality Device in Patients With Ischemic Stroke in the Early Subacute Recovery Phase: Study Protocol for a Phase III, Single-Blinded, Randomized, Controlled Clinical Trial [J] . Nima Ahmed, Vitor A Queiroz Mauad, Olga Gomez-Rojas, Journal of Central Nervous System Disease . 2020 ,第4期

机译：恢复恢复的虚拟现实装置对早期亚急性回收阶段缺血性卒中患者的影响：研究方案，用于III期，单盲，随机，受控临床试验
4. Development of the iPAM MkII system and description of a randomized control trial with acute stroke patients [C] . Jackson A.E., Levesley M.C., Makower S.G., 2013 IEEE 13th International Conference on Rehabilitation Robotics . 2013

机译：iPAM MkII系统的开发以及急性卒中患者的随机对照试验说明
5. A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil (Eicosapentaenoic Acid and Docosahexaenoic Acid) on Lung and Systemic Inflammation in Patients with Acute Lung Injury. [D] . Stapleton, Renee Doney. 2010

机译：鱼油（二十碳五烯酸和二十二碳六烯酸）对急性肺损伤患者的肺和全身炎症的II期，随机，双盲，安慰剂对照试验。
6. Remote Ischemic Conditioning After Stroke Trial 2: A Phase IIb Randomized Controlled Trial in Hyperacute Stroke [O] . Timothy J. England, Amanda Hedstrom, Saoirse E. OSullivan, 2019

机译：中风试验后的远程缺血条件治疗2：超急性中风的IIb期随机对照试验
7. Remote Ischemic Conditioning After Stroke Trial 2: A Phase IIb Randomized Controlled Trial in Hyperacute Stroke [O] . Timothy J. England, Amanda Hedstrom, Saoirse E. OSullivan, 2019

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Dodecafluoropentane Emulsion in Acute Ischemic Stroke: A Phase Ib/II Randomized and Controlled Dose-Escalation Trial

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