Microsatellite instability and mismatch repair protein expression in sebaceous tumors, keratocanthoma, and basal cell carcinomas with sebaceous differentiation in Muir-Torre syndrome

摘要

To the Editor: Recently the Journal of the American Academy of Dermatology featured an interesting article by Lee et al investigating the frequency of internal malignancies in patients with sebaceous tumors. We read this article -with interest, and we would like to highlight some aspects and express the following concerns regarding this report: Within the wide Muir-Torre syndrome (MTS) tumor spectrum, peculiar MTS-associated cutaneous tumors include not only sebaceous adenomas, but also sebaceomas and carcinomas, keratoacan-thoma (KA), basal cell carcinoma (BCC) with sebaceous differentiation and seboacanthomas constitute the peculiar MTS-associated cutaneous tumors.The authors focused on sebaceous tumors and confirmed that a solitary sebaceous tumor does not exclude MTS. However, we would like to remark that the diagnosis of a solitary KA, associated with at least one internal malignancy, can also define a possible MTS phenotype.