Prehypertension is real and can be associated with target organ damage

摘要

Abstract Prehypertension (systolic blood pressure 120139 or diastolic blood pressure 8089爉m Hg) confers a risk of progression to hypertension, impairment of cognitive function, increased left ventricular mass, risk of end-stage renal disease, and an association with arteriosclerosis. Recent studies provide data that could support the rationale for treating prehypertensives subjects with antihypertensive medications in addition to lifestyle modification, especially if they have concomitant cardiovascular risk factors. Highlights " Prehypertension increases the incidence of significant target organ damage. " Target organ damage includes progression to hypertension, cognitive impairment, left ventricular mass, end-stage renal disease, and arteriosclerosis. " Drug treatment of systolic blood pressure 130139爉m Hg confers a significant benefit. " Drug treatment of the 120129爉m Hg systolic blood pressure range also confers a benefit, although less. " Drug treatment may be appropriate for prehypertensive patients with risk factors.