Solubility and Solution Thermodynamic Properties of 4-(4-Hydroxyphenyl)-2-butanone (Raspberry Ketone) in Different Pure Solvents

摘要

The solubility of 4-(4-hydroxyphenyl)-2-butanone (raspberry ketone) in six pure solvents was experimentally determined at temperatures ranging from 283.15 to 313.15 K under the pressure 0.10 MPa by employing a gravimetrical method. The experimental results indicate that the solubility of raspberry ketone in all studied solvents is temperature dependent, a rise in temperature brings about an increase in solubility. The experimental solubility data of raspberry ketone in six pure solvents (acetone, ethanol, ethyl acetate, n-propyl alcohol, n-butyl alcohol, and distilled water) was correlated by using several commonly used thermodynamic models, including the Apelblat, van't Hoff and lambda h equations. The results of the error analysis indicate that the van't Hoff equation was able to give more accurate and reliable predictions of solubility with root-mean-square deviation less than 0.56%. Furthermore, the changes of dissolution enthalpies (Delta H-diss degrees), dissolution entropies (Delta S-diss degrees) and dissolution Gibbs energies (Delta(diss)G degrees) of raspberry ketone in the solvents studied were estimated by the van't Hoff equation. The positive value of Delta H-diss degrees, Delta S-diss degrees, and Delta(diss)G degrees indicated that these dissolution processes of raspberry ketone in the solvents studied were all endothermic and enthalpy-driven.