Production, quality control of next-generation PET radioisotope iodine-124 and its thyroid imaging

摘要

In this paper, Te-124(p,n)I-124 nuclear reaction was used for I-124 production. The (TeO2)-Te-124/Al2O3 target was irradiated by 12.5MeV proton at 20 A for 3-8h in a medical cyclotron. After irradiation, I-124 was purified by dry distillation and dissolved in 0.02M NaOH, with radioactivity 370-1480MBq. Micro-PET/CT imaging of I-124 in healthy mice showed the thyroid and stomach accumulations and kidney metabolism, which may be useful for thyroid disease diagnosis. In summary, we have produced next-generation PET radioisotope I-124 routinely in sufficient and high quality.