Combinatorial functionalization with bisurea‐peptides and antifouling bisurea additives of a supramolecular elastomeric biomaterial

Ippel Bastiaan D.; Arts Boris; Keizer Henk M.; Dankers Patricia Y. W.

摘要

ABSTRACT > The bioactive additive toolbox to functionalize supramolecular elastomeric materials expands rapidly. Here we have set an explorative step toward screening of complex combinatorial functionalization with antifouling and three peptide‐containing additives in a bisurea‐based supramolecular system. Thorough investigation of surface properties of thin films with contact angle measurements, X‐ray photoelectron spectroscopy and atomic force microscopy, was correlated to cell‐adhesion of endothelial and smooth muscle cells to apprehend their respective predictive values for functional biomaterial development. Peptides were presented at the surface alone, and in combinatorial functionalization with the oligo(ethylene glycol)‐based non‐cell adhesive additive. The bisurea‐RGD additive was cell‐adhesive in all conditions, whereas the endothelial cell‐specific bisurea‐REDV showed limited bioactive properties in all chemical nano‐environments. Also, aspecific functionality was observed for a bisurea‐SDF1α peptide. These results emphasize that special care should be taken in changing the chemical nano‐environment with peptide functionalization. ? 2019 The Authors. Journal of Polymer Science Part B: Polymer Physics published by Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019 , 57, 1725–1735 </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 生物活性添加剂工具箱官能化超分子弹性体材料迅速膨胀。在这里，我们对基于双粥样半粥样系统中的防污和含三种肽添加剂进行了促进复杂组合官能化的探索步骤。具有接触角测量的薄膜表面性质，X射线光电子能谱和原子力显微镜的彻底研究与内皮和平滑肌细胞的细胞粘附相关，以控制其各自的功能性生物材料的预测值。肽单独呈现在表面上，并用寡核苷酸（乙二醇）的非细胞粘合剂添加剂组合官能化。在所有条件下，Bisurea-RGD添加剂是细胞粘合剂，而内皮细胞特异性Bisurea-Redv在所有化学纳米环境中显示出有限的生物活性性质。此外，对Bisurea-SDF1α肽观察到的显效功能。这些结果强调应采用肽官能化改变化学纳米环境来进行特别注意。还2019年作者。聚合物科学第B部分：聚合物物理</ i> 由Wiley期刊，Inc.J. Mover出版。 SCI。，B部分：聚合物。物理。 2019 </ b> ，57,1725-1735 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35627/'>《Journal of Polymer Science, Part B. Polymer Physics》</a> <b style="margin: 0 2px;">|</b><span>2019年第24期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ippel Bastiaan D.&option=202" target="_blank" rel="nofollow">Ippel Bastiaan D.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Arts Boris&option=202" target="_blank" rel="nofollow">Arts Boris;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Keizer Henk M.&option=202" target="_blank" rel="nofollow">Keizer Henk M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dankers Patricia Y. W.&option=202" target="_blank" rel="nofollow">Dankers Patricia Y. W.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Institute for Complex Molecular SystemsEindhoven University of TechnologyPO Box 513 5600 Eindhoven Manitoba The Netherlands;</p> <p>Institute for Complex Molecular SystemsEindhoven University of TechnologyPO Box 513 5600 Eindhoven Manitoba The Netherlands;</p> <p>SyMO‐Chem B.VDen Dolech 2 5612 Eindhoven Arizona The Netherlands;</p> <p>Institute for Complex Molecular SystemsEindhoven University of TechnologyPO Box 513 5600 Eindhoven Manitoba The Netherlands;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1185.html" title="高分子化学（高聚物）">高分子化学（高聚物）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=additives&option=203" rel="nofollow">additives;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biointerfaces&option=203" rel="nofollow">biointerfaces;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=peptides&option=203" rel="nofollow">peptides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=screening&option=203" rel="nofollow">screening;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=supramolecular biomaterials&option=203" rel="nofollow">supramolecular biomaterials;</a> </p> <div class="translation"> 机译：添加剂;生物界面;肽;筛选;超分子生物材料; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025810859.html">Combinatorial functionalization with bisurea‐peptides and antifouling bisurea additives of a supramolecular elastomeric biomaterial</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ippel Bastiaan D.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ippel Bastiaan D.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Arts Boris&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Arts Boris,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Keizer Henk M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Keizer Henk M.,</a> <a href="/journal-foreign-35627/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Polymer Science, Part B. 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