Trial to detect significant metrics for drug-induced seizure liability using microelectrode arrays data analysis and primary rodent neurons: From multi-site pilot study of the HESI NeuTox consortium in collaboration with CSAHi and iNCENS

Miyamoto Norimasa; Ojima Atsuko; Inaba Saori; Kitamura Tetsuo; Osada Tomoharu; Yoshinaga Takashi

首页> 外文期刊>Journal of Pharmacological and Toxicological Methods >Trial to detect significant metrics for drug-induced seizure liability using microelectrode arrays data analysis and primary rodent neurons: From multi-site pilot study of the HESI NeuTox consortium in collaboration with CSAHi and iNCENS

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Trial to detect significant metrics for drug-induced seizure liability using microelectrode arrays data analysis and primary rodent neurons: From multi-site pilot study of the HESI NeuTox consortium in collaboration with CSAHi and iNCENS

机译：试验以使用微电极阵列数据分析和原发性啮齿动物神经元检测药物诱导的癫痫责任的重要指标：从HESI中毒素联盟的多站点试验研究与CSAHI合作，促进

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来源
《Journal of Pharmacological and Toxicological Methods》 |2019年第2019期|共4页
作者
Miyamoto Norimasa; Ojima Atsuko; Inaba Saori; Kitamura Tetsuo; Osada Tomoharu; Yoshinaga Takashi;
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作者单位

Eisai &

Co Ltd Med Dev Ctr Biopharmaceut Assessments Core Funct Unit Tsukuba Ibaraki Japan;

Eisai &

Co Ltd Med Dev Ctr Biopharmaceut Assessments Core Funct Unit Tsukuba Ibaraki Japan;

Eisai &

Co Ltd Med Dev Ctr Biopharmaceut Assessments Core Funct Unit Tsukuba Ibaraki Japan;

LSI Med Corp Nonclin Res Ctr Safety Assessment Dept Kamisu Japan;

Consortium Safety Assessment iPS Cells CSAHi Kawasaki Kanagawa Japan;

Eisai &

Co Ltd Med Dev Ctr Biopharmaceut Assessments Core Funct Unit Tsukuba Ibaraki Japan;

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正文语种 eng
中图分类药理学;
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1. Trial to detect significant metrics for drug-induced seizure liability using microelectrode arrays data analysis and primary rodent neurons: From multi-site pilot study of the HESI NeuTox consortium in collaboration with CSAHi and iNCENS [J] . Miyamoto Norimasa, Ojima Atsuko, Inaba Saori, Journal of Pharmacological and Toxicological Methods . 2019,第期

机译：试验以使用微电极阵列数据分析和原发性啮齿动物神经元检测药物诱导的癫痫责任的重要指标：从HESI中毒素联盟的多站点试验研究与CSAHI合作，促进
2. Characterization of neural networks of human induced pluripotent stem cell-derived neurons-Report from iPS non-clinical experiments for nervous system (iNCENS) project in collaboration with CSAHi and HESI NeuTox [J] . Takahashi Kanako, Chujo Kaori, Kanda Yasunari, Journal of Pharmacological and Toxicological Methods . 2019,第期

机译：人类诱导多能干细胞源神经元神经网络的特征 - 从IPS非临床实验与CSAHI和HESI UETIOS合作
3. CSAHi study: Detection of drug-induced seizure-like activities of three convulsants at five facilities using micro-electrode arrays in combination with human iPS cell-derived neurons [J] . Ishibashi Yuto, Odawara Aoi, Shirakawa Takafumi, Journal of Pharmacological and Toxicological Methods . 2019,第期

机译：CSAHI研究：使用微电极阵列与人IPS细胞衍生神经元组合的五种设施在五种设施中检测药物诱导的癫痫发作的活性。
4. Method for MEA Data Analysis of Drug-treated Rat Primary Neurons and Human iPSC-derived Neurons to Evaluate the Risk of Drug-induced Seizures [O] . Atsuko Ojima, Norimasa Miyamoto 2018

机译：药物治疗的大鼠原发性神经元和人IPSC衍生神经元的MEA数据分析方法，以评估药物诱导的癫痫发作的风险

Trial to detect significant metrics for drug-induced seizure liability using microelectrode arrays data analysis and primary rodent neurons: From multi-site pilot study of the HESI NeuTox consortium in collaboration with CSAHi and iNCENS

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