received (131)I at a mean dosage of 3.50 +/- 0.37 GBq did not show chromosome damage within 48 h from the end of radiometabolic therapy. This may be due to a prompt activation of the cell machinery that maintains the integrity of the genome to prevent harmful double-strand breaks from progressing to chromosome mutations, either by repairing the lesions or by eliminating the most seriously damaged cells via apoptosis.

摘要

Adolescent; Apoptosis; Cell Nucleus; Child; Chromosomes; DNA Damage; DNA Repair; Female; Gene Expression Profiling; Genome; Half-Life; Humans; Iodine Radioisotopes; Male; Micronucleus Tests; Oligonucleotide Array Sequence Analysis; T-Lymphocytes; Thyroid Neoplasms; Thyroidectomy