Acellular vaccines for preventing pertussis in children.

摘要

Clinical Question Are acellular vaccines as safe and effective as whole-cell vaccines for preventing pertussis (whooping cough) in children? Evidence-Based Answer Multicomponent (i.e., three or more) acellular vaccines are as effective as whole-cell vaccines at preventing pertussis and mild pertussis disease (e.g., cold symptoms, cough without classic whoop or cough paroxysms) in children. Adverse effects are similar to those from placebo and less severe than those from whole-cell vaccines. (Strength of Recommendation = A , based on consistent, good-quality patient-oriented evidence.)